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Introduction

We are a bioinformatics research group in the Department of Biomedical Informatics at Harvard Medical School. We are part of the Ludwig Center at HarvardDivision of Genetics at Brigham and Women's Hospital and Harvard-MIT Division of Health, Science, & Technology

Our main aim is to understand the genetic and epigenetic mechanisms that underlie disease processes through computational and statistical analysis of genomic data. We are particularly interested in mutational processes in normal and cancer cells and their impact in gene regulation. 

Collaborative science

We have the privilege of collaborating with a number of superb experimental laboratories at Harvard Medical School and its affiliated hospitals, as well as around the world. Our recent and current collaborators include Connie Cepko, George Daley, Steve Elledge, Konrad Hochedlinger, Mark Johnson, Mitzi Kuroda, Jordan Kreidberg, Bob Kingston, William Pu, Charlie Roberts, Chris Walsh, Fred Winston.

Here are some consortium projects in which we are involved:

  • 4D Nucleome - What are the principles underlying three-dimensional organization of the human genome? What is the role of the nuclear architecture in gene regulation? As the Data Coordination and Analysis Center for this major NIH initiative, we will collect, process, and display all data generated in the consortium and to perform integrative analysis. Main collaborators: Peter Kharchenko (HMS), Leonid Mirny (MIT), Nils Gehlenborg (HMS), Hanspeter Pfister (Harvard) and Ting Wang (WashU).
  • Brain Somatic Mosaicism Network - The aim of this network is to characterize the spectrum of somatic variation in human brain samples and its role in psychiatric disorders. We are studying somatic mosaicism in autism with Chris Walsh (Boston Children's) and schizophrenia with Andy Chess (Mt. Sinai).
  • Ludwig Center - This center brings together investigators from across Harvard to develop strategies to overcome the problem of therapy resistence in cancer.
  • International Cancer Genome Consortium - This is an effort by the international cancer genomics community to jointly analyze ~2,500 cancer genomes.

Our research is supported by: 

Park Lab Research Support

@ParkLabGenomics

Latest News

Cancer Research UK

Cancer Research UK's Grand Challenge

March 11, 2019

The Park lab has been funded by Cancer Research UK’s Grand Challenge, which provides £20M over 5 years to a team to work on toughest problems in cancer research. Our team, led by our long-time collaborator Steve Elledge, includes a number of investigators from US/UK/Netherlands. We will attempt to understand why there is such tissue-specificity in cancer drivers--i.e., why one oncogene causes cancer in one tissue but does not in another.

Learn...

Read more about Cancer Research UK's Grand Challenge
4DN data portal

At the annual meeting of the 4D Nucleome consortium

December 5, 2018
Members of the DCIC (Data Coordination and Integration Center) traveled to San Diego for the Annual Meeting of the 4D Nucleome project. From the HMS group were curators Andy, Koray, Sarah, and Luisa; postdoctoral fellows Su Wang and Hu Jin; and co-leaders Burak and Peter.  Peter gave a talk outlining the superb work that the team has been doing all year. Particularly impressive were the beautiful web interface by Alex Balashov, 4DN JupyterHub by Carl, and and publication pages by our curators.  Check it out: https://data.4dnucleome.org/ Read more about At the annual meeting of the 4D Nucleome consortium
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