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Introduction

We are a bioinformatics research group in the Department of Biomedical Informatics at Harvard Medical School. We are part of the Ludwig Center at HarvardDivision of Genetics at Brigham and Women's Hospital and Harvard-MIT Division of Health, Science, & Technology

Our main aim is to understand the genetic and epigenetic mechanisms that underlie disease processes through computational and statistical analysis of genomic data. We are particularly interested in mutational processes in normal and cancer cells and their impact in gene regulation. 

Collaborative science

We have the privilege of collaborating with a number of superb experimental laboratories at Harvard Medical School and its affiliated hospitals, as well as around the world. Our recent and current collaborators include Connie Cepko, George Daley, Steve Elledge, Konrad Hochedlinger, Mark Johnson, Mitzi Kuroda, Jordan Kreidberg, Bob Kingston, William Pu, Charlie Roberts, Chris Walsh, Fred Winston.

Here are some consortium projects in which we are involved:

  • 4D Nucleome - What are the principles underlying three-dimensional organization of the human genome? What is the role of the nuclear architecture in gene regulation? As the Data Coordination and Analysis Center for this major NIH initiative, we will collect, process, and display all data generated in the consortium and to perform integrative analysis. Main collaborators: Peter Kharchenko (HMS), Leonid Mirny (MIT), Nils Gehlenborg (HMS), Hanspeter Pfister (Harvard) and Ting Wang (WashU).
  • Brain Somatic Mosaicism Network - The aim of this network is to characterize the spectrum of somatic variation in human brain samples and its role in psychiatric disorders. We are studying somatic mosaicism in autism with Chris Walsh (Boston Children's) and schizophrenia with Andy Chess (Mt. Sinai).
  • Ludwig Center - This center brings together investigators from across Harvard to develop strategies to overcome the problem of therapy resistence in cancer.
  • International Cancer Genome Consortium - This is an effort by the international cancer genomics community to jointly analyze ~2,500 cancer genomes.

Latest News

Finding mutations in single neurons, in collaboration with the Walsh Lab

December 7, 2017

Congratulations to Craig Bohrson, Alison Barton, and Daniel Kwon, three of the six co-lead authors of a recently published paper in Science, discussing the increased accumulation of mutations in neurons as people age. The paper was the result of a collaborative effort with the Walsh Lab of Boston Children's Hospital. The link to the paper is here; the paper was featured in...

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A Closer Read: To understand large data sets, researchers look to tools that decipher patterns in natural language

December 4, 2017

Dr. Peter Park and Dr. Doga Gulhan were featured in an article in the Harvard Medicine Magazine last month, which describes their current work on the computational analysis of genomics data of cancer patients. 

You can read the article here.

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October Lab Hike in New Hampshire

November 16, 2017

On October 13th, members of the Park lab went on the annual lab hiking trip. This year, they hiked the Welch and Dickey loop trail of the White Mountains in New Hampshire. This was the first New Englad hiking experience for many of our fellows who've come from abroad! 

Pictures from the trip can be found...

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