Spatiotemporal Evolution of the Primary Glioblastoma Genome.

Citation:

Kim J, Lee I-H, Cho HJ, Park C-K, Jung Y-S, Kim Y, Nam SH, Kim BS, Johnson MD, Kong D-S, Seol HJ, Lee J-I, Joo KM, Yoon Y, Park W-Y, Lee J, Park PJ**, Nam D-H**. Spatiotemporal Evolution of the Primary Glioblastoma Genome. Cancer Cell 2015;28(3):318-28. Copy at http://www.tinyurl.com/y4msvs6z
Spatiotemporal Evolution of the Primary Glioblastoma Genome.

Date Published:

2015 Sep 14

Abstract:

Tumor recurrence following treatment is the major cause of mortality for glioblastoma multiforme (GBM) patients. Thus, insights on the evolutionary process at recurrence are critical for improved patient care. Here, we describe our genomic analyses of the initial and recurrent tumor specimens from each of 38 GBM patients. A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor. In addition, in contrast to IDH1-mutated gliomas, IDH1-wild-type primary GBMs rarely developed hypermutation following temozolomide (TMZ) treatment, indicating low risk for TMZ-induced hypermutation for these tumors under the standard regimen.

Last updated on 10/21/2015