@article {664771,
	title = {Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.},
	journal = {Cell},
	volume = {164},
	number = {3},
	year = {2016},
	month = {2016 Jan 28},
	pages = {550-63},
	abstract = {
	Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined that ATRX but not TERT promoter mutations are associated with increased telomere length. Recent advances in glioma classification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis of DNA methylation profiles, which identified clinically relevant molecular subsets. A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival. Understanding of cohesive disease groups may aid improved clinical outcomes.

},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2015.12.028},
	author = {Ceccarelli, Michele and Barthel, Floris P and Malta, Tathiane M and Sabedot, Thais S and Salama, Sofie R and Murray, Bradley A and Morozova, Olena and Newton, Yulia and Radenbaugh, Amie and Pagnotta, Stefano M and Anjum, Samreen and Wang, Jiguang and Manyam, Ganiraju and Zoppoli, Pietro and Ling, Shiyun and Rao, Arjun A and Grifford, Mia and Cherniack, Andrew D and Zhang, Hailei and Poisson, Laila and Carlotti, Carlos Gilberto and Tirapelli, Daniela Pretti da Cunha and Rao, Arvind and Mikkelsen, Tom and Lau, Ching C and Yung, W K Alfred and Rabadan, Raul and Huse, Jason and Brat, Daniel J and Lehman, Norman L and Barnholtz-Sloan, Jill S and Zheng, Siyuan and Hess, Kenneth and Rao, Ganesh and Meyerson, Matthew and Beroukhim, Rameen and Cooper, Lee and Akbani, Rehan and Wrensch, Margaret and Haussler, David and Aldape, Kenneth D and Laird, Peter W and Gutmann, David H and TCGA Research Network and Noushmehr, Houtan and Iavarone, Antonio and Verhaak, Roel G W}
}
