@article {582901,
	title = {The Molecular Taxonomy of Primary Prostate Cancer.},
	journal = {Cell},
	volume = {163},
	number = {4},
	year = {2015},
	month = {2015 Nov 5},
	pages = {1011-25},
	abstract = {
	There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74\% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25\% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19\%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects.

},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2015.10.025},
	author = {Cancer Genome Atlas Research Network, TCGA}
}
