@article {564071,
	title = {Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster.},
	journal = {Genes Dev},
	volume = {19},
	number = {19},
	year = {2005},
	month = {2005 Oct 1},
	pages = {2289-94},
	abstract = {
	A long-standing model postulates that X-chromosome dosage compensation in Drosophila occurs by twofold up-regulation of the single male X, but previous data cannot exclude an alternative model, in which male autosomes are down-regulated to balance gene expression. To distinguish between the two models, we used RNA interference to deplete Male-Specific Lethal (MSL) complexes from male-like tissue culture cells. We found that expression of many genes from the X chromosome decreased, while expression from the autosomes was largely unchanged. We conclude that the primary role of the MSL complex is to up-regulate the male X chromosome.

},
	keywords = {Animals, Cell Line, Dosage Compensation, Genetic, Drosophila melanogaster, Drosophila Proteins, Male, Multiprotein Complexes, Up-Regulation, X Chromosome},
	issn = {0890-9369},
	doi = {10.1101/gad.1343705},
	author = {Hamada, Fumika N and <b>Park, Peter J</b> and Gordadze, Polina R and Kuroda, Mitzi I}
}
