@article {564026,
	title = {The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.},
	journal = {Nat Genet},
	volume = {40},
	number = {6},
	year = {2008},
	month = {2008 Jun},
	pages = {794-9},
	abstract = {
	According to the prevailing view, mammalian X chromosomes are enriched in spermatogenesis genes expressed before meiosis and deficient in spermatogenesis genes expressed after meiosis. The paucity of postmeiotic genes on the X chromosome has been interpreted as a consequence of meiotic sex chromosome inactivation (MSCI)--the complete silencing of genes on the XY bivalent at meiotic prophase. Recent studies have concluded that MSCI-initiated silencing persists beyond meiosis and that most genes on the X chromosome remain repressed in round spermatids. Here, we report that 33 multicopy gene families, representing approximately 273 mouse X-linked genes, are expressed in the testis and that this expression is predominantly in postmeiotic cells. RNA FISH and microarray analysis show that the maintenance of X chromosome postmeiotic repression is incomplete. Furthermore, X-linked multicopy genes exhibit a similar degree of expression as autosomal genes. Thus, not only is the mouse X chromosome enriched for spermatogenesis genes functioning before meiosis, but in addition, approximately 18\% of mouse X-linked genes are expressed in postmeiotic cells.

},
	keywords = {Animals, DNA Probes, Gene Dosage, Gene Expression Regulation, Developmental, Genes, X-Linked, In Situ Hybridization, Fluorescence, Male, Meiosis, Mice, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, RNA Probes, RNA, Messenger, Spermatogenesis, Spermatozoa, Testis, X Chromosome},
	issn = {1546-1718},
	doi = {10.1038/ng.126},
	author = {Mueller, Jacob L and Mahadevaiah, Shantha K and <b>Park, Peter J</b> and Warburton, Peter E and Page, David C and Turner, James M A}
}
