@article {563986,
	title = {Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X.},
	journal = {Genes Dev},
	volume = {23},
	number = {19},
	year = {2009},
	month = {2009 Oct 1},
	pages = {2266-71},
	abstract = {
	Dosage compensation in Drosophila melanogaster males is achieved via targeting of male-specific lethal (MSL) complex to X-linked genes. This is proposed to involve sequence-specific recognition of the X at approximately 150-300 chromatin entry sites, and subsequent spreading to active genes. Here we ask whether the spreading step requires transcription and is sequence-independent. We find that MSL complex binds, acetylates, and up-regulates autosomal genes inserted on X, but only if transcriptionally active. We conclude that a long-sought specific DNA sequence within X-linked genes is not obligatory for MSL binding. Instead, linkage and transcription play the pivotal roles in MSL targeting irrespective of gene origin and DNA sequence.

},
	keywords = {Animals, Dosage Compensation, Genetic, Drosophila melanogaster, Drosophila Proteins, Gene Expression Regulation, Male, X Chromosome},
	issn = {1549-5477},
	doi = {10.1101/gad.1840409},
	author = {Gorchakov, Andrey A and Alekseyenko, Artyom A and <b>Kharchenko, Peter</b> and <b>Park, Peter J</b> and Kuroda, Mitzi I}
}
