@article {563876,
	title = {Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila.},
	journal = {Genes Dev},
	volume = {27},
	number = {8},
	year = {2013},
	month = {2013 Apr 15},
	pages = {853-8},
	abstract = {
	Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.

},
	keywords = {Animals, Dosage Compensation, Genetic, Drosophila melanogaster, Drosophila Proteins, Evolution, Molecular, Female, Karyotype, Male, Molecular Sequence Data, Sex Chromosomes},
	issn = {1549-5477},
	doi = {10.1101/gad.215426.113},
	author = {Alekseyenko, Artyom A and Ellison, Christopher E and Gorchakov, Andrey A and Zhou, Qi and Kaiser, Vera B and Toda, Nick and Walton, Zaak and <b>Peng, Shouyong</b> and <b>Park, Peter J</b> and Bachtrog, Doris and Kuroda, Mitzi I}
}
