@article {546836, title = {Hallmarks of pluripotency.}, journal = {Nature}, volume = {525}, number = {7570}, year = {2015}, month = {2015 Sep 23}, pages = {469-78}, abstract = { Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance. }, issn = {1476-4687}, doi = {10.1038/nature15515}, author = {De Los Angeles, Alejandro and Ferrari, Francesco and Xi, Ruibin and Fujiwara, Yuko and Benvenisty, Nissim and Deng, Hongkui and Hochedlinger, Konrad and Jaenisch, Rudolf and Lee, Soohyun and Leitch, Harry G and Lensch, M William and Lujan, Ernesto and Pei, Duanqing and Rossant, Janet and Wernig, Marius and Park, Peter J and Daley, George Q} }