@article {393296,
	title = {Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.},
	journal = {Cell},
	volume = {158},
	number = {4},
	year = {2014},
	month = {2014 Aug 14},
	pages = {929-44},
	abstract = {
	Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We\&nbsp;performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung\&nbsp;squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.

},
	keywords = {Cluster Analysis, Humans, Neoplasms, Transcriptome},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2014.06.049},
	author = {Hoadley, Katherine A and Yau, Christina and Wolf, Denise M and Cherniack, Andrew D and Tamborero, David and Ng, Sam and Leiserson, Max D M and Niu, Beifang and McLellan, Michael D and Uzunangelov, Vladislav and Zhang, Jiashan and Kandoth, Cyriac and Akbani, Rehan and Shen, Hui and Omberg, Larsson and Chu, Andy and Margolin, Adam A and Van{\textquoteright}t Veer, Laura J and Lopez-Bigas, Nuria and Laird, Peter W and Raphael, Benjamin J and Ding, Li and Robertson, A Gordon and Byers, Lauren A and Mills, Gordon B and Weinstein, John N and Van Waes, Carter and Chen, Zhong and Collisson, Eric A and Cancer Genome Atlas Research Network, The Cancer Genome Atlas and Benz, Christopher C and Perou, Charles M and Stuart, Joshua M}
}
