@article {393251,
	title = {p53 prevents neurodegeneration by regulating synaptic genes.},
	journal = {Proc Natl Acad Sci U S A},
	volume = {111},
	number = {50},
	year = {2014},
	month = {2014 Dec 16},
	pages = {18055-60},
	abstract = {
	DNA damage has been implicated in neurodegenerative disorders, including Alzheimer{\textquoteright}s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a neuroprotective role in a Drosophila model of tauopathy. Further, through a whole-genome ChIP-chip analysis, we identify genes controlled by p53 in postmitotic neurons. We genetically validate a specific pathway, synaptic function, in p53-mediated neuroprotection. We then demonstrate that the control of synaptic genes by p53 is conserved in mammals. Collectively, our results implicate synaptic function as a central target in p53-dependent protection from neurodegeneration.

},
	issn = {1091-6490},
	doi = {10.1073/pnas.1419083111},
	author = {Merlo, Paola and Frost, Bess and <b>Peng, Shouyong</b> and Yang, Yawei J and <b>Park, Peter J</b> and Feany, Mel}
}
