@article {153016,
	title = {Epigenetics meets next-generation sequencing.},
	journal = {Epigenetics},
	volume = {3},
	number = {6},
	year = {2008},
	month = {2008 Nov},
	pages = {318-21},
	abstract = {
	Next-generation sequencing is poised to unleash dramatic changes in every area of molecular biology. In the past few years, chromatin immunoprecipitation (ChIP) on tiled microarrays (ChIP-chip) has been an important tool for genome-wide mapping of DNA-binding proteins or histone modifications. Now, ChIP followed by direct sequencing of DNA fragments (ChIP-seq) offers superior data with less noise and higher resolution and is likely to replace ChIP-chip in the near future. We will describe advantages of this new technology and outline some of the issues in dealing with the data. ChIP-seq generates considerably larger quantities of data and the most challenging aspect for investigators will be computational and statistical analysis necessary to uncover biological insights hidden in the data.

},
	keywords = {Animals, Chromatin Immunoprecipitation, Cooperative Behavior, Epigenesis, Genetic, Humans, Nucleosomes, Sequence Analysis, DNA},
	issn = {1559-2308},
	author = {<b>Park, Peter J</b>}
}
