@article {1024801,
	title = {ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice},
	journal = {Nat Genet},
	volume = {49},
	number = {2},
	year = {2017},
	month = {2017 Feb},
	pages = {296-302},
	abstract = {
	Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in \~{}20\% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here we demonstrate that Arid1a functions as a tumor suppressor in the mouse colon, but not the small intestine, and that invasive ARID1A-deficient adenocarcinomas resemble human colorectal cancer (CRC). These tumors lack deregulation of APC/β-catenin signaling components, which are crucial gatekeepers in common forms of intestinal cancer. We find that ARID1A normally targets SWI/SNF complexes to enhancers, where they function in coordination with transcription factors to facilitate gene activation. ARID1B preserves SWI/SNF function in ARID1A-deficient cells, but defects in SWI/SNF targeting and control of enhancer activity cause extensive dysregulation of gene expression. These findings represent an advance in colon cancer modeling and implicate enhancer-mediated gene regulation as a principal tumor-suppressor function of ARID1A.

},
	issn = {1546-1718},
	doi = {10.1038/ng.3744},
	author = {Mathur, Radhika and <b>Alver, Burak H</b> and San Roman, Adrianna K and Wilson, Boris G and Wang, Xiaofeng and Agoston, Agoston T and <b>Park, Peter J</b> and Shivdasani, Ramesh A and Roberts, Charles W M}
}
