Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".

Citation:

Ferrari F*, Jung YL*, Kharchenko PV, Plachetka A, Alekseyenko AA, Kuroda MI, Park PJ. Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters". Science 2013;340(6130):273. Copy at http://www.tinyurl.com/yy359ohe

Date Published:

2013 Apr 19

Abstract:

Conrad et al. (Reports, 10 August 2012, p. 742) reported a doubling of RNA polymerase II (Pol II) occupancy at X-linked promoters to support 5' recruitment as the key mechanism for dosage compensation in Drosophila. However, they employed an erroneous data-processing step, overestimating Pol II differences. Reanalysis of the data fails to support the authors' model for dosage compensation.

Last updated on 10/19/2015