Algorithm settings used in Lai et al. (2005) CGHseg (default settings -- note that the sign of S is different between the value given in Picard et al. and the value given in the MATLAB code... the implementations are actually identical because a negative sign was implicitly removed in the MATLAB code): Km = 20, S = 0.5 Quantreg (following Eilers and de Menezes's tuning recommendation): lambda = 1.5, tau = 0.5 CLAC (default settings): windowsize = 5, targetFDR = 0.01 GLAD (default settings): mediancenter = FALSE, smoothfunc = "lawsglad", bandwidth = 10, round = 2, model = "Gaussian", lkern = "Exponential", qlambda = 0.999, base = FALSE, sigma = NULL, lambdabreak = 8, lambdacluster = 8, lambdaclusterGen = 40, type = "tricubic", param = c(d = 6), alpha = 0.001, msize = 5, method = "centroid", nmax = 8 CBS (default settings): alpha = 0.01, nperm = 10000, window.size = NULL, overlap = 0.25, trim = 0.025, undo.splits = "none", undo.prune = 0.05, undo.SD = 3 HMM (default settings): vr = 0.01, maxiter = 100, aic = TRUE, bic = TRUE, delta = NA, model.use = 1, minDiff = 0.25, maxmadUse = 0.3, maxmedUse = 0.5, maxState = 3, minClone = 20, factor = 5, maxClones = 1, maxLen = 1000, absValSingle = 1, absValRegion = 1, diffVal1 = 1, diffVal2 = 0.5, maxSize = 10000, pChrom.min = 0.9, medChrom.min = 0.1) Wavelet (following results of Hsu et al.): n.levels = 3, hard = FALSE Lowess (our implementation): w = 10 (meaning use a window size of 10), iter = 3, delta = 0 ChARM (default settings): meanPcutoff = 0.01, signPcutoff = 0.001, signTest = 1 GA (turn off amplification cutoff threshold): amplificationThreshold = 100 (effectively turns off the threshold parameter because the default checkbox code has a bug) ACE (our selection since an target FDR was not given): targetFDR = 0.001